Premedication of Oral Clonidine 2mcg/kg and 4mcg/kg for Analgesic and Pressure Response During First Twenty-four Hours After Upper Abdominal Surgery: A Comparative Study

Traditionally postoperative period analgesia was maintained by opoids and which frequently increasethe hospital stay time cost delayed bowel movement others side effects. on the other handupper abdominal surgery is very much painful, usually Opiods are used as good analgesic, but havesome adverse effect addiction effect; anaesthesiologists want to reduce its requirements. In upperabdominal adequate analgesia, stable haemodynamic, early movement, free from nauseaand vomiting wanted, a part of multimodal analgesic approach, premedication clonidine veryimportant for it angiolytic sedative properties. Alpha two (α–2) adrenoreceptor agonist,Clonidine exerts central sympatholytic 8 10 hours half life 9-12 h. So thatpremedication with oral causes reduction anxiety, perioperative analgesicdrugs also anaesthetic doses. addition, increases cardiac baroreceptorreflex sensitivity increase in systolic blood pressure, thus stabilizes pressure. Clonidine israpidly almost completely absorbed after administration maximum plasmaconcentration between 1.5 2 hr elimination half-life 12 hr. But producesanalgesia dose dependent manner, achieving complete pain relief up 5 without sensoryor motor block at large doses (oral 7000 900 mcg) however doss were associated withdisadvantage including hypotension, bradycardia transient sedation. It reported thatclonidine 150mcg intravenous (I/V) produce similar morphine 5mg patient afterorthopedic surgery. Because dose, route, surgical variation important tospecify upper surgery.The primary aim this study compare effects different (2 &4mcg/kg) hemodynamic status largeincision area. (like- hepatobiliary surgery, gastrectomy, esophagectomy, hepatictomy, whipplesoperations). JBSA 2022; 35 (2) : 17-21